High-intensity resistance training in multiple sclerosis - An exploratory study of effects on immune markers in blood and cerebrospinal fluid, and on mood, fatigue, health-related quality of life, muscle strength, walking and cognition. Kierkegaard M, Lundberg IE, Olsson T, Johansson S, Ygberg S, Opava C, et al.But aerobic activity along with interferon beta-1 treatment, more effectively led to an increase in IL-10 of serum and a decrease in serum TNF-α in MS + INF-β + running wheel group compared to MS + solvent + running wheel group (compared to exercise or medication alone) (P = 0.001).Conclusion: Aerobic activity along with medication may possibly lead to clinical improvement and quality of life in patients with MS by controlling inflammatory factors. Finally, blood samples were taken from the heart and data analysis was done using one-way ANOVA test.Findings: TNF-α levels in the MS+INF-β group significantly reduced compared to the MS + solvent group (P = 0.0010), and a significant increase was observed in the amount of IL-10 in comparison with the same groups (P = 0.01). The interferon beta drug protocol in amount of 150 IU/g as well as the 4-week protocol of voluntary aerobic exercise with running wheel were administered to the treatment groups. To induce of Experimental Autoimmune Encephalomyelitis (EAE), mixture of myelin oligodendrocyte glycoprotein (MOG) (35-55) was injected subcutaneously, and pertussis toxin was injected intraperitoneally. The Aim of this study was to evaluate the effect of 4 weeks of voluntary aerobic activity along with interferon beta on the serum levels of tumor necrosis factor alfa (TNF-α) and interleukin 10 (IL-10) in mice model of multiple sclerosis.Methods: In this experimental study, a total number of 80 female mice were divided into eight groups. Background: The anti-inflammatory effects of exercise in chronic diseases are mediated by a decrease in pro-inflammatory cytokines and an increase in anti-inflammatory cytokines.
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